SELECTED PUBLICATIONS

2021

The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination. (Cell)

Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection. (PLoS)

IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques. (Nature)

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs. (Immunity)

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques. (Cell)

Systems vaccinology of the BNT162b2 mRNA vaccine in humans. (Nature)

2020

Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination. (Vaccines)

Transcriptomic and Metabolic Responses to a Live-Attenuated Francisella tularensis Vaccine. (Vaccines)

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. (Nature)

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+cells. (Nature)

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance. (Cell)

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques. (Cell)

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans. (Cell)

2019

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance. (Cell)

West Nile Virus-Inclusive Single-Cell RNA Sequencing Reveals Heterogeneity in the Type 1 Interferon Responses within Single Cells. (J Virol)

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans. (Cell)

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization. (Cell)

2018

Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication. (PLoS Pathog)

Progestin-based contraception regimens modulate expression of putative HIV risk factors in the vaginal epithelium of pig-tailed Macaques. (Am J Reprod Immunol)

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. (Immunity)

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. (Sci Transl Med)

Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV Cure Strategies. (Front Immunol)

Short-term pIFN-α2a treatment does not significantly reduce the viral reservoir of SIV-infected, ART-treated rhesus macaques. (J Virol)

Correlates of Protection Against SIVmac251 Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors. (EBioMedicine)

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. (Nat Commun)

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data. (Genome Med)

Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques. (J Virol)

Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. (Nature)

2017

The IDO inhibitor 1-methyl tryptophan activates the aryl hydrocarbon receptor response in mesenchymal stromal cells. (Oncotarget)

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation. (Science)

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques. (J Virol)

The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and prevention. (Mucosal Immunol)

Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection. (PNAS)